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What is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world's most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question. What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms--in particular, the supremely well-researched bacterium E. coli--because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements. It integrates the writhings and couplings of billions of molecules into a coherent whole, draws matter and energy into itself, constructs and reproduces its own order, and persists in this manner for numberless generations while continuously adapting to a changing world. A cell constitutes a unitary whole, a unit of life, and in this volume one of the leading authorities on the cell gives us a vivid picture of what goes on within this minute precinct. The result is a richly detailed, meticulously crafted account of what modern science can tell us about life as well as one scientist's personal attempt to wring understanding from the tide of knowledge.
The new sixth edition of this best-selling introduction to biochemistry maintains the clarity and coherence that so appeals to students whilst incorporating the very latest advances in the field, new worked examples and end of chapter problems and an improved artwork programme to highlight key processes and important lessons.
The book introduces a radically new way of thinking about information and the important role it plays in living systems. It opens up new avenues for exploring how cells and organisms change and adapt, since the ability to detect and respond to meaningful information is the key that enables them to receive their genetic heritage, regulate their internal milieu, and respond to changes in their environment. It also provides a way of resolving Descartes’ dilemma by explaining the workings of the brain in non-mechanical terms that are not tainted by spiritual or metaphysical beliefs. The types of meaningful information that different species and different cell types are able to detect are finely matched to the ecosystem in which they live, for natural selection has shaped what they need to know to function effectively in those circumstances. Biological detection and response systems range from the chemical configurations that govern genes and cell life to the relatively simple tropisms that guide single-cell organisms, the rudimentary nervous systems of invertebrates, and the complex neuronal structures of mammals and primates. The scope of meaningful information that can be detected and responded to reaches its peak in our own species, as exemplified by our special abilities in language, cognition, emotion, and consciousness, all of which are explored within this new framework.
To Make the World Intelligible: A Scientist’s Journey is both a book about a life of science and about the science of life. In it, Franklin M. Harold shares the story of his life as a German immigrant, who lived in the Middle East before coming to America and finding his place in life as a scientist. But Harold’s story does not stand in isolation. It is set against the heyday of biochemistry and molecular biology: a time when the staid science of biology was being transformed from a descriptive study of animals and plants into an intense inquiry into how living things work at the level of cells and molecules. Harold then builds on this backdrop by sharing some of his research and that of his mentor and Nobel Prizewinner Peter Mitchell, as well as his insights and reflections on life as a phenomenon of nature. The accessible, comprehensive, and yet lyrical way that Harold accomplishes this is a testament to his belief that a scientist’s raison d’être is to make the world intelligible.
This pathbreaking book explores how life can begin, taking us from cosmic clouds of stardust, to volcanoes on Earth, to the modern chemistry laboratory. Seeking to understand life’s connection to the stars, David Deamer introduces astrobiology, a new scientific discipline that studies the origin and evolution of life on Earth and relates it to the birth and death of stars, planet formation, interfaces between minerals, water, and atmosphere, and the physics and chemistry of carbon compounds. Deamer argues that life began as systems of molecules that assembled into membrane-bound packages. These in turn provided an essential compartment in which more complex molecules assumed new functions required for the origin of life and the beginning of evolution. Deamer takes us from the vivid and unpromising chaos of the Earth four billion years ago up to the present and his own laboratory, where he contemplates the prospects for generating synthetic life. Engaging and accessible, First Life describes the scientific story of astrobiology while presenting a fascinating hypothesis to explain the origin of life.
Wilhelm Reich’s experiments in the 1930s with cutting-edge light microscopy and time-lapse micro-cinematography were considered discredited, but not because of shoddy lab technique, as has been claimed. Scientific opposition to Reich’s experiments, James Strick argues, grew out of resistance to his unorthodox sexual theories and Marxist leanings.
Controversial Supreme Court decisions have barred organized school prayer, but neither the Court nor public policy exclude religion from schools altogether. In this book, one of America's leading constitutional scholars asks what role religion ought to play in public schools. Kent Greenawalt explores many of the most divisive issues in educational debate, including teaching about the origins of life, sex education, and when--or whether--students can opt out of school activities for religious reasons. Using these and other case studies, Greenawalt considers how to balance the country's constitutional commitment to personal freedoms and to the separation of church and state with the vital role that religion has always played in American society. Do we risk distorting students' understanding of America's past and present by ignoring religion in public-school curricula? When does teaching about religion cross the line into the promotion of religion? Tracing the historical development of religion within public schools and considering every major Supreme Court case, Greenawalt concludes that the bans on school prayer and the teaching of creationism are justified, and that the court should more closely examine such activities as the singing of religious songs and student papers on religious topics. He also argues that students ought to be taught more about religion--both its contributions and shortcomings--especially in courses in history. To do otherwise, he writes, is to present a seriously distorted picture of society and indirectly to be other than neutral in presenting secularism and religion. Written with exemplary clarity and even-handedness, this is a major book about some of the most pressing and contentious issues in educational policy and constitutional law today.

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