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Systems Biology of Clostridium provides a comprehensive overview of system biology approaches in clostridia, especially Clostridium acetobutylicum. Systems biology is a rapidly evolving scientific discipline that allows us to understand and predict the metabolism and its changes within the bacterium as a whole. Clostridia represent one of the largest bacterial genera. This group contains organisms with metabolic properties that hold enormous potential for biotechnological processes. A model organism is Clostridium acetobutylicum that has been, and is still used in large-scale industrial production of the solvents acetone and butanol. Systems biology offers a new way to elucidate and understand the complex regulatory network controlling the different metabolic pathways and their interactions. All aspects from the development of appropriate experimental tools to mathematical modeling are covered, including a fascinating historical account on acetone-butanol fermentation in World War II. Written by world-class experts in their fields, Systems Biology of Clostridium is an essential source of reference for all biologists, biochemists, chemists, and chemical engineers working on biotechnological fermentations or industrial applications, as well as biofuels. Contents:Metabolic and Regulatory Networks in Clostridium AcetobutylicumClostridial Gene ToolsSupporting Systems Biology of Clostridium Acetobutylicum by Proteome AnalysisComparative Genomic Analysis of the General Stress Response in Clostridium Acetobutylicum ATCC 824 and Clostridium Beijerinckii NCIMB 8052Mathematical Modeling of the pH-Induced Metabolic Shift in Clostridium AcetobutylicumMathematical Models for Clostridia: From Cultivation Description to Systems BiologyModeling Agr-Dependent Quorum Sensing in Gram-Positive BacteriaComparative Genomic Analysis of the Central Metabolism of the Solventogenic Species Clostridium acetobutylicum ATCC 824 and Clostridium Beijerinckii NCIMB 8052The Strategic Importance of Biobutanol for Japan During WWII: A Case Study of the Butanol Fermentation Process in Taiwan and Japan Readership: Biologists, chemists, biochemists and chemical engineers working on biotechnological fermentations or industrial applications in biofuels. Key Features:First comprehensive overview of systems biology in the genus ClostridiumAuthors are world class experts in the fieldKeywords:Clostridium Acetobutylicum;Metabolic Network;Regulatory Network;proteome Analysis;Systems Biology
"In this book internationally recognized Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research." --Book Jacket.
Advances in Endospore-Forming Bacteria Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Endospore-Forming Bacteria Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Endospore-Forming Bacteria Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Molecular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
This volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on biochemistry and physiology but topics of clinical relevance are included. Contributions from leading authorities Informs and updates on all the latest developments in the field
Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known, giving rise to genome-scale reconstructed biochemical reaction networks underlying cellular functions. Mathematical descriptions of the totality of these chemical interactions lead to genome-scale models that allow the computation of physiological functions. Reflecting these recent developments, this textbook explains how such quantitative and computable genotype-phenotype relationships are built using a genome-wide basis of information about the gene portfolio of a target organism. It describes how biological knowledge is assembled to reconstruct biochemical reaction networks, the formulation of computational models of biological functions, and how these models can be used to address key biological questions and enable predictive biology. Developed through extensive classroom use, the book is designed to provide students with a solid conceptual framework and an invaluable set of modeling tools and computational approaches.
Thisisthe?rstissueofanewjournaloftheLNCSjournalsubline.Theaimofthe journal is to encourage inter- and multidisciplinary research in the ?elds of c- puter science and life sciences. The recent paradigmatic shift in biology towards a system view of biological phenomena requires a corresponding paradigmatic shift in the techniques from computer science that can face the new challenges. Classical tools usually used in bioinformatics are no longer up to date and new ideas are needed. The convergence of sciences and technologies we are experiencing these days is changing the classical terms of reference for research activities. In fact clear distinctions between disciplines no longer exist because advances in one ?eld permit advances in others and vice versa, thus establishing a positive feedback loop between sciences. The potential impact of the convergence of sciences and technologies is so huge that we must consider how to control and correctly drive our future activities. International and national funding agencies are looking at interdisciplinary research as a key issue for the coming years, especially in the intersection of life sciences and information technology. To speed up this process, we surely need to establish relationships between researchers of di?erent communities and to de?ne a common language that will allow them to exchange ideas and - sults. Furthermore, expectations of di?erent communities can be merged only by running activities like common projects and experiences. TheTransactionsonComputationalSystemsBiologycouldbeagoodforumto helplifescientistsandcomputerscientiststodiscusstogethertheircommongoals.

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