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Systems Biology of Clostridium provides a comprehensive overview of system biology approaches in clostridia, especially Clostridium acetobutylicum. Systems biology is a rapidly evolving scientific discipline that allows us to understand and predict the metabolism and its changes within the bacterium as a whole. Clostridia represent one of the largest bacterial genera. This group contains organisms with metabolic properties that hold enormous potential for biotechnological processes. A model organism is Clostridium acetobutylicum that has been, and is still used in large-scale industrial production of the solvents acetone and butanol. Systems biology offers a new way to elucidate and understand the complex regulatory network controlling the different metabolic pathways and their interactions. All aspects from the development of appropriate experimental tools to mathematical modeling are covered, including a fascinating historical account on acetone-butanol fermentation in World War II. Written by world-class experts in their fields, Systems Biology of Clostridium is an essential source of reference for all biologists, biochemists, chemists, and chemical engineers working on biotechnological fermentations or industrial applications, as well as biofuels. Contents:Metabolic and Regulatory Networks in Clostridium AcetobutylicumClostridial Gene ToolsSupporting Systems Biology of Clostridium Acetobutylicum by Proteome AnalysisComparative Genomic Analysis of the General Stress Response in Clostridium Acetobutylicum ATCC 824 and Clostridium Beijerinckii NCIMB 8052Mathematical Modeling of the pH-Induced Metabolic Shift in Clostridium AcetobutylicumMathematical Models for Clostridia: From Cultivation Description to Systems BiologyModeling Agr-Dependent Quorum Sensing in Gram-Positive BacteriaComparative Genomic Analysis of the Central Metabolism of the Solventogenic Species Clostridium acetobutylicum ATCC 824 and Clostridium Beijerinckii NCIMB 8052The Strategic Importance of Biobutanol for Japan During WWII: A Case Study of the Butanol Fermentation Process in Taiwan and Japan Readership: Biologists, chemists, biochemists and chemical engineers working on biotechnological fermentations or industrial applications in biofuels. Key Features:First comprehensive overview of systems biology in the genus ClostridiumAuthors are world class experts in the fieldKeywords:Clostridium Acetobutylicum;Metabolic Network;Regulatory Network;proteome Analysis;Systems Biology
"In this book internationally recognized Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research." --Book Jacket.
Advances in technological and analytical methods have fostered rapid growth of systems biology and synthetic biology. There continues to be rapid changes and discoveries in both fields with a small number of recent peer-reviewed reviews indicating some of the relationships between systems biology and synthetic biology. This proposed SpringerBrief will cover core concepts of systems biology and synthetic biology and illustrate the implementation of associated research methodologies for an integrated approach to specifically address engineering microorganisms for biofuel production.​
This volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on biochemistry and physiology but topics of clinical relevance are included. Contributions from leading authorities Informs and updates on all the latest developments in the field
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Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Molecular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Clostridia is one of the largest bacterial genera with an enormous potential for biotechnical and medical applications. Despite growing scientific, medical, and industrial interest, information on basic methods, biochemical fundamentals, clinical practice, industrial applications, and novel developments remains scattered in a variety of research articles, reviews, and book chapters. Responding to this gap in the literature, Handbook on Clostridia combines all of these topics into a single volume. The editor takes a global approach by presenting information on both Clostridia of biotechnological importance and Clostridia of medical importance. Experts in the field summarize methods, physiology, medical significance, regulation, ecosystems, genomics, and current and potential applications. Providing a comprehensive resource on the complete field of Clostridium, this book also serves as a compilation of critical reviews on the advantages of using Clostridia for new medical and biotechnological applications. It is a valuable reference for every specialist, researcher, and student involved in this promising field.

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