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This authoritative book provides readers with a comprehensive view of advanced nuclear analytical techniques for metallomics and metalloproteomics.
This international collection of chapters comprehensively covers different aspects of procedures for speciation analysis at all levels starting from sample collection and storage, through sample preparation approaches to render the species chromatographable, principles of separation techniques used in speciation analysis, to the element specific detection. International renowned editors and contributors Includes coverage of electrochemical methods, biosensors for metal ions, radioisotope techniques and direct solid speciation techniques Provides information on quality assurance and risk assessment, and speciation-relevant legislation Each chapter is a stand-alone reference covering a given facet of elemental speciation analysis written by an expert in a given field with the volume as a whole providing an excellent introductory text and reference handbook.
In the past several decades, the research on spin transport and magnetism has led to remarkable scientific and technological breakthroughs, including Albert Fert and Peter Grünberg’s Nobel Prize-winning discovery of giant magnetoresistance (GMR) in magnetic metallic multilayers. Handbook of Spin Transport and Magnetism provides a comprehensive, balanced account of the state of the art in the field known as spin electronics or spintronics. It reveals how key phenomena first discovered in one class of materials, such as spin injection in metals, have been revisited decades later in other materials systems, including silicon, organic semiconductors, carbon nanotubes, graphene, and carefully engineered nanostructures. The first section of the book offers a historical and personal perspective of the field written by Nobel Prize laureate Albert Fert. The second section addresses physical phenomena, such as GMR, in hybrid structures of ferromagnetic and normal metals. The third section discusses recent developments in spin-dependent tunneling, including magnetic tunnel junctions with ferroelectric barriers. In the fourth section, the contributors look at how to control spin and magnetism in semiconductors. In the fifth section, they examine phenomena typically found in nanostructures made from metals, superconductors, molecular magnets, carbon nanotubes, quantum dots, and graphene. The final section covers novel spin-based applications, including advanced magnetic sensors, nonvolatile magnetoresistive random access memory, and semiconductor spin-lasers. The techniques and materials of spintronics have rapidly evolved in recent years, leading to vast improvements in hard drive storage and magnetic sensing. With extensive cross-references between chapters, this seminal handbook provides a complete guide to spin transport and magnetism across various classes of materials and structures.
Aimed at newcomers, students and the experienced practitioner, this book is an accessible and applicable guide to quantitative problem solving in vacuum technology.
Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .
In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
A comprehensive, practical guide, this textbook is ideally suited for graduate students in physics and chemistry starting XAFS-based research.

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