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In recent years there have been significant advances in the knowledge of risk factors, gene-environment interactions, incidence, prevalence, outcomes, and prevention strategies of many neurological disorders. These advances have been accompanied by developments in study design methodologies and statistical analysis. This handbook bridges the gap between current neuroepidemiological knowledge and its evidence-based application in everyday practice.
Neuroepidemiology covers the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system. The etiology of many important central nervous system disorders remains elusive. Even with diseases where the key risk determinants have been identified, better prevention and therapy is needed to reduce high incidence and mortality. Although evolving technologies for studying disease provide opportunities for such, it is essential for researchers and clinicians to understand how best to apply such technology in the context of carefully characterized patient populations. By paying special attention to methodological approaches, this volume prepares new investigators from a variety of disciplines to conduct epidemiological studies in order to discern the etiologic factors and underlying mechanisms that influence the onset, progression, and recurrence of CNS disorders and diseases. The book also provides current information on methodological approaches for clinical neurologists seeking to expand their knowledge in research. Includes coverage of the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system Describes the most recent methodologies to define and quantify the burden of CNS disorders and to understand the underlying mechanisms, with neuroimaging and molecular methods receiving particular emphasis Offers extensive description of those neurological conditions that are secondary to other diseases whose incidence is on the rise because of longer survival rates Features chapters authored by leaders in the field from around the globe
The discipline of neurology emerged in the second half of the 19th Century. With it, chairs and departments of neurology, training programs, specialized journals, and new societies came into being. Trying to understand disorders of the nervous system, however, has roots that can be traced back into antiquity, and the new discipline did not develop in similar ways throughout the world. Further, whereas some neurological disorders seemed relatively easy to understand even before there was a neurological examination, others posed challenges, and many still remain shrouded in mystery. The authors of the present volume examine the fascinating prehistory of neurology, its emergence with as an independent discipline, and how it developed throughout the world. They also look at a number of neurological disorders, some sensory, others motor, and still others affecting higher cognitive functions, to illustrate how our understanding of neurological disorders has changed over time. With 55 chapters, many covering material that has received little or no coverage in other books, this history of neurology is unique in its breadth and depth. Filling a great void, its pages are laced with fascinating medical facts, information about people, and cultural connections. This volume is sure to appeal to neurologists, historians of science and medicine, and inquisitive people from other fields --- readers who wish to understand the roots of a discipline and the challenges faced by its pioneers.
As a collection of neuroepidemiology papers, this book captures the range and excitement of the discipline. Researchers in the field have been at the forefront in the study of slow viruses, retroviral epidemiology, chronic neuroloical diseases, as well as injuries and other disabilities of the neurological system. The intersection of epidemiology, neurology, and behavioral/social science is a unique feature of this book. Furthermore, Molgaard's collection differs from similar titles in that it focuses on minorities and international work in neuroepidemiology. * Covers the patterns and risk factors of the epidemiology of neurologic disease and disorders * Studies chronic disease epidemiology * Presents research methods in public health
Neuro-Otology: a volume in the Handbook of Clinical Neurology series, provides a comprehensive translational reference on the disorders of the peripheral and central vestibular system. The volume is aimed at serving clinical neurologists who wish to know the most current established information related to dizziness and disequilibrium from a clinical, yet scholarly, perspective. This handbook sets the new standard for comprehensive multi-authored textbooks in the field of neuro-otology. The volume is divided into three sections, including basic aspects, diagnostic and therapeutic management, and neuro-otologic disorders. Internationally acclaimed chapter authors represent a broad spectrum of areas of expertise, chosen for their ability to write clearly and concisely with an eye toward a clinical audience. The Basic Aspects section is brief and covers the material in sufficient depth necessary for understanding later translational and clinical material. The Diagnostic and Therapeutic Management section covers all of the essential topics in the evaluation and treatment of patients with dizziness and disequilibrium. The section on Neuro-otologic Disorders is the largest portion of the volume and addresses every major diagnostic category in the field. Synthesizes widely dispersed information on the anatomy and physiology of neuro-otologic conditions into one comprehensive resource Features input from renowned international authors in basic science, otology, and neuroscience Presents the latest assessment of the techniques needed to diagnose and treat patients with dizziness, vertigo, and imbalance Provides the reader with an updated, in-depth review of the clinically relevant science and the clinical approach to those disorders of the peripheral and central vestibular system
This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology. Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on molecular medicine. These advances are particularly important today with the introduction of emerging and re-emerging diseases such as HIV/AIDS, Nipah encephalitis and the appearance of West Nile encephalitis in the western hemisphere. Detailed coverage of neurovirology from the basic science to clinical presentation Covers advances in neurovirology via polymerase chain reaction (PCR) and MRI technology Covers emerging and re-emerging diseases including HIV/AIDS, Nipah encephalitis, and the appearance of West Nile encephalitis in the western hemisphere
Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS. This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners. A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options Each chapter is translational and focuses on current research and impact on diagnosis and treatment options

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