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From quantum theory to statistical mechanics, the methodologies of physics are often used to explain some of life's most complex biological problems. Exploring this challenging yet fascinating area of study, Molecular and Cellular Biophysics covers both molecular and cellular structures as well as the biophysical processes that occur in these structures. Designed for advanced undergraduate and beginning graduate students in biophysics courses, this textbook features a quantitative approach that avoids being too abstract in its presentation. Logically organized from small-scale (molecular) to large-scale (cellular) systems, the text first defines life, discussing the scientific controversies between mechanists and vitalists, the characteristics of living things, and the evolution of life. It then delves into molecular structures, including nucleic acids, DNA, RNA, interatomic interactions, and hydrogen bonds. After looking at these smaller systems, the author probes the larger cellular structures. He examines the cytoplasm, the cytoskeleton, chromosomes, mitochondria, motor proteins, and more. The book concludes with discussions on biophysical processes, including oxidative phosphorylation, diffusion, bioenergetics, conformational transitions in proteins, vesicle transport, subcellular structure formation, and cell division.
With an emphasis on numerical modeling, Physics of the Sun: A First Course presents a quantitative examination of the physical structure of the Sun and the conditions of its extended atmosphere. It gives step-by-step instructions for calculating the numerical values of various physical quantities. The text covers a wide range of topics on the Sun and stellar astrophysics, including the structure of the Sun, solar radiation, the solar atmosphere, and Sun-space interactions. It explores how the physical conditions in the visible surface of the Sun are determined by the opacity of the material in the atmosphere. It also presents the empirical properties of convection in the Sun and discusses how the physical parameters increase with depth through the convection zone. The author shows how certain types of "real stars" are actually polytropes and offers a simplified version of oscillation equations to highlight the properties of p- and g-modes in the Sun. He also focuses on the initial temperature rise into the chromosphere, why the temperature in the quiet corona has the value it does, and how the physics of magnetic fields help us to understand various striking phenomena that are observed on the Sun. This text enables a practical appreciation of the physical models of solar processes. Through the included numerical modeling problems, it encourages a firm grasp of the numerical values of actual physical parameters as a function of radial location in the Sun.
Molecular biophysics is a rapidly growing field of research that plays an important role in elucidating the mysteries of life's molecules and their assemblies, as well as the relationship between their structure and function. Introduction to Molecular Biophysics fills an existing gap in the literature on this subject by providing the reader with the modern theoretical tools needed to understand life processes from a physical viewpoint. The authors review numerous topics of relevance to biophysics, including peptide chains, DNA structure and function, cytoplasm, membranes, and motor proteins. Each chapter is richly illustrated and contains numerous examples, references, and problems that make this book useful as both an inclusive reference work and textbook.
Taking a conceptual approach to the subject, Concepts in Quantum Mechanics provides complete coverage of both basic and advanced topics. Following in the footsteps of Dirac’s classic work Principles of Quantum Mechanics, it explains all themes from first principles. The authors present alternative ways of representing the state of a physical system, outline the mathematical connection between the representatives of the same state in different representations, and highlight the connection between Dirac brackets and their integral forms in the coordinate and momentum representations. They also logically develop the equations of motion in Schrödinger and Heisenberg pictures. In addition, the book covers motion in the presence of potential steps and wells, bound state problems, symmetries and their consequences, the role of angular momentum in quantum mechanics, approximation methods, time-dependent perturbation methods, and second quantization. Written by authoritative professors who have taught quantum mechanics at the graduate level for a combined forty years, this textbook provides students with a strong foundation in quantum mechanics. After reading the book, students will be ready to take on quantum field theory.
This book presents the fundamentals of molecular biophysics, and highlights the connection between molecules and biological phenomena, making it an important text across a variety of science disciplines. The topics covered in the book include: Phase transitions that occur in biosystems (protein crystallisation, globule-coil transition etc) Liquid crystallinity as an example of the delicate range of partially ordered phases found with biological molecules How molecules move and propel themselves at the cellular level The general features of self-assembly with examples from proteins The phase behaviour of DNA The physical toolbox presented within this text will form a basis for students to enter into a wide range of pure and applied bioengineering fields in medical, food and pharmaceutical areas.
The study of dielectric properties of biological systems and their components is important not only for fundamental scientific knowledge but also for its applications in medicine, biology, and biotechnology. The associated technique - known as dielectric spectroscopy - has enabled researchers to quickly and accurately acquire time- or frequency-spectra of permittivity and conductivity and permitted the derivation and testing of realistic electrical models for cells and organelles. This text covers the theoretical basis and practical aspects of the study of dielectric properties of biological systems, such as water, electrolyte and polyelectrolytes, solutions of biological macromolecules, cells suspensions and cellular systems. The authors' combined efforts provide a comprehensive and cohesive book that takes advantage of the expertise of multiple scientists involved in cutting-edge research in the specific sub-fields of bio-dielectric spectroscopy while maintaining its self-consistency through numerous discussions. The first six chapters cover theoretical, methodological and experimental aspects of relaxation and dispersion in biological dielectrics at molecular, cellular and cellular aggregate level. Applications are presented in the following chapters which are organized in the order of increased complexity, beginning with pure water, amino acids and proteins, continuing with vesicles and simple cells such as erythrocytes, and then with more complex, organelle-containing cells and cellular aggregates. Due to its broad coverage, the text could be used as a reference book by researchers, and as a textbook for upper-level undergraduate classes and graduate classes in (bio) physics, medical physics, quantitative biology, and engineering.