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Latest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health.
This authoritative book provides readers with a comprehensive view of advanced nuclear analytical techniques for metallomics and metalloproteomics.
The book that looks at mercury's impact on the planet today Recent research by the EPA has concluded that one in six women of childbearing age have unsafe levels of mercury in their bodies, which puts 630,000 newborn babies each year at risk of neurological impairment. Mercury poses severe risks to the health of animals and ecosystems around the world, and this book provides the essential information that anyone interested in environmental sciences should know about the fundamentals of the entire mercury cycle. Comprised of four parts that present an overview of mercury in the environment, mercury transformations, transport, and bioaccumulation and toxicology, each chapter of Environmental Chemistry and Toxicology of Mercury includes the basic concepts of the targeted subject, a critical review of that subject, and the future research needs. This book explains the environmental behavior and toxicological effects of mercury on humans and other organisms, and provides a baseline for what is known and what uncertainties remain in respect to mercury cycling. The chapters focus on the fundamental science underlying the environmental chemistry and fate of mercury. This work will be invaluable to a wide range of policy experts, environmental scientists, and other people requiring a comprehensive source for the state of the science in this field.
Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more
This practical guide for advanced students and decision-makers in the pharma and biotech industry presents key success factors in R&D along with value creators in pharmaceutical innovation. A team of editors and authors with extensive experience in academia and industry and at some of the most prestigious business schools in Europe discusses in detail the innovation process in pharma as well as common and new research and innovation strategies. In doing so, they cover collaboration and partnerships, open innovation, biopharmaceuticals, translational medicine, good manufacturing practice, regulatory affairs, and portfolio management. Each chapter covers controversial aspects of recent developments in the pharmaceutical industry, with the aim of stimulating productive debates on the most effective and efficient innovation processes. A must-have for young professionals and MBA students preparing to enter R&D in pharma or biotech as well as for students on a combined BA/biomedical and natural sciences program.
This book describes nerve agents and vesicants, their decomposition and their degradation products' chemistry as well as their toxicity including a list of detection techniques of nerve agents and their degradation products. This book will present their history, toxicity, comparison between different sample preparation methods, separation techniques, and detection methods all together in a short, easy to read book, tied together by a single group doing the writing and the editing to assure smooth transition from chapter to chapter, with sufficient Tables and literature references for the reader who looks to further detail.The text will illustrate the pluses and minuses of the various techniques with sufficient references for the reader to obtain extensive detail.

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