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Written for practitioners in the field, this critically acclaimed bestseller provides authoritative information focused on the investigation of drug-related deaths and practical approaches to the detection of drug abuse. Organized to provide forensic investigators and pathologists with ready access to the authoritative and comprehensive information they need, Karch’s Pathology of Drug Abuse, Fourth Edition includes— • 171 new color photos and microphotographs • 46 tables of comparative information • 2,000 new references to the literature Authored by a World-Renowned Forensic Pathologist Steven B. Karch is a fellow in several forensic and toxicological societies and has served many years as consultant to both the legal community and the pharmaceutical industry in the United States and the United Kingdom. His bestselling resources can be found on the bookshelves of forensic experts and pathologists across the world. They include the classic Drug Abuse Handbook, and A Brief History of Cocaine, both in their second editions, available from CRC Press.
The Pathology of Drug Abuse, Fifth Edition is a comprehensive yet accessible guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book also offers detailed information on the origin, history, and production techniques used to make these drugs. As in the first edition, emphasis remains focused on the investigation of drug-related deaths and on practical approaches to the detection of drug abuse. The medical complications associated with each of the abused drugs are discussed in some detail as well. Individual chapters examine cocaine and other naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, and solvent abuse. Approximately 800 new references have been added since the publication of the first edition. Numerous new photomicrographs and drawings have been added, and many of the illustrations from the first edition have been redrawn to enhance clarity. Steven B. Karch discusses the book in a video on the CRC Press YouTube channel.
AUTHORITATIVE INFORMATION FROM THE SOURCE YOU TRUST The third edition of Karch's Pathology of Drug Abuse continues to provide a comprehensive yet accessible guide to the pathology, toxicology, and pharmacology of commonly abused drugs. As in previous editions, the focus remains on the investigation of drug-related deaths and on practical approaches to the detection of drug abuse. It covers in detail the clinical consequences of drug usage and provides the latest information on clinical aspects of drug abuse. This well-written, extensively referenced resource supplies a mixture of clinical information and pathology findings. SEE WHAT'S NEW IN THE THIRD EDITION: New information on methamphetamine abuse New chapter on GHB, ketamine, and select herbal hallucinogens New micrographs showing pathology of drug related deaths Over 1000 new references The mechanism of sudden death in cocaine users and overdose in heroin abusers Toxicology and pathology of ephedrine Neurochemistry of excited delirium Psychotic behavior in stimulant abusers About the author: Steven B. Karch has appeared as an expert witness in international cases, including advice to counsel in the Harold Shipman murder trial. He is an assistant medical examiner in San Francisco, where he consults on cases of drug-related deaths. He received his bachelors degree from Brown University, did graduate work in cell biology and biophysics at Stanford, and received his M.D. from Tulane University Medical School.
Following the well-received first edition, the Drug Abuse Handbook, Second Edition is a thorough compendium of the knowledge of the pharmacological, medical, and legal aspects of drugs. The book examines criminalistics, pathology, pharmacokinetics, neurochemistry, treatment, as well as drugs and drug testing in the workplace and in sports, and the ethical, legal, and practical issues involved. Dr. Karch gathers contributions from 80 leading experts in their respective fields to update and revise this second edition with more than 40 percent new material. New topics include genetic testing in drug death investigation, the neurochemistry of nicotine and designer amphetamines, genetic doping in sports, and the implications of the Daubert ruling on the admissibility of scientific evidence in federal court. Packed with the latest information in an easily accessible format, the book includes tables of all Scheduled Drugs, methods of Drug Quantitative Analysis, and a glossary of forensic toxicology terms. Vivid pictures and diagrams illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. It includes more than 6000 references to the best sources in medicine, pharmacology, and the law. This book addresses specific problems in drug testing, drug-related medical emergencies, and the physical, neurochemical, and sociological phenomenon of addiction. With unparalleled detail and the highest level of authoritative information, The Drug Abuse Handbook, Second Edition is the definitive resource for drug related issues.
Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Pathology, Toxicogenetics, and Criminalistics of Drug Abuse presents a detailed introduction to the cutting-edge advances in this emerging field. Beginning with a definition and explanation of the scheduling of controlled substances, the book covers all illicit drugs, as well as several legitimate pharmaceutical preparations that are used illicitly, including steroids. It describes in detail the most common pathologic syndromes seen in the hearts, lungs, and central nervous systems of drug abusers and explains how inherited genetic defects and variations can alter drug effects. Written by leading investigators in the field, this useful volume describes the techniques most commonly used by forensic analysts including chemical confirmatory tests such as microcrystal identification and gas chromatography/mass spectrometry. The book reviews the basics of toxicogenetics, including the molecular changes in cardiac structure ("channelopathies") that may cause sudden death.
Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Addiction and the Medical Complications of Drug Abuse explores the physiological and psychological phenomenon of addiction including the nature of dependence, the dependence potential of drugs, and the importance of motivation. Contributions analyze the practice of substitute prescribing and detail the immediate and long term benefits of their use in maintenance or controlled withdrawal from opioids, stimulants, and benzodiazepines. It considers the use of methadone, buprenorphine, adrenergic agonists, and naltrexone for detoxification. Practitioners will benefit from the expert instruction on the management of common comorbidities, including diagnosis and pharmaceutical treatment of psychological disorders. Additional information covers the physiological effects of each drug and the emergency management of several drug related disorders such as psychosis, seizures, stroke, hyperthermia, and cardiac crisis. With 29 tables and figures, expert data and extensive references, this is an indispensable book for anyone in the field of addiction or emergency medicine.
Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Beginning with a detailed look at individual drugs and their effects on the brain, Neurochemistry of Abused Drugs considers the changes in neurotransmitter levels and discusses the relationship of these changes to the nature and phenomenon of addiction. New studies highlight the addictive capacity of nicotine as well as introduce novel compounds that may aid in tobacco cessation. Chapters examine nicotine dependant neuroplasticity and the various neurochemical substrates that support and promote addiction including cholinergic, dopaminergic, and GABAergic adaptations. The book also offers detailed information on the neurochemical and neurobehavioral consequences of MDMA, methamphetamine, and cocaine use. Recent discoveries on the neurotransmitter systems involved in each of these drugs reveal new therapeutic targets for alleviating addiction including ibogaine, and GABA and glutamate receptors. Extensively referenced and citing numerous up-to-date studies, this book provides unparalleled insight into the action and potential inhibition of drugs of abuse.

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