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Drawing on current research, the expertise of health professionals in 50 countries, and emerging trends in both public and clinical health, this graduate-level textbook delivers an evidence-based examination of global health challenges in population health and wellbeing. It emphasizes innovative and transformative approaches to public health practice, curricula, and leadership and is framed by the “fifth wave” of public health, a biopsychosocial model of health and social care. The text builds on the findings of the seminal Lancet commission report, “Health professions for a new century: transforming education to strengthen health systems in an interdependent world,” and is grounded in the recognition of the complex interdependence of natural, socio-economic, and political systems at local, national, regional, and global levels.