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This application-oriented textbook covers theory and practice of modern NMR applications, from complex stucture elucidation to biomolecular interaction and reaction control. The author is a former co-worker of Nobel laureate Kurt Wuthrich.
Protein NMR Spectroscopy: Principles and Practice combines a comprehensive theoretical treatment of high resolution NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules. Beginning with simple theoretical models and experimental techniques, Protein NMR Spectroscopy: Principles and Practice develops the complete repertoire of theoretical principals and experimental practices necessary for understanding and implementing the most sophisticated NMR experiments. Protein NMR Spectroscopy: Principles and Practice is written as a graduate-level textbook and will be of particular interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy as a research tool or who wish to remain abreast of the latest developments in this increasingly important area. * Special Features: * First book to combine detailed NMR theory discussions with experimental applications to biomolecules. * All the theory required to understand these experiments and others. * Easy to follow progression from a fundamental level to an advanced level. * Theory of NMR and practical applications for biomolecular investigations presented. * Theory applied to very practical situations. * Comprehensive treatment of different "levels" of theory from simple ideas to density matrix analysis and operator practices. * Comprehensive description of multi dimensional NMR experiments as applied to unlabeled, 15N-labeled and doubly (13C/15N) labeled proteins.
Nuclear Magnetic Resonance is a powerful tool, especially for the identification of 1 13 hitherto unknown organic compounds. H- and C-NMR spectroscopy is known and applied by virtually every synthetically working Organic Chemist. Con- quently, the factors governing the differences in chemical shift values, based on chemical environment, bonding, temperature, solvent, pH, etc. , are well understood, and specialty methods developed for almost every conceivable structural challenge. Proton and carbon NMR spectroscopy is part of most bachelors degree courses, with advanced methods integrated into masters degree and other graduate courses. In view of this universal knowledge about proton and carbon NMR spectr- copy within the chemical community, it is remarkable that heteronuclear NMR is still looked upon as something of a curiosity. Admittedly, most organic compounds contain only nitrogen, oxygen, and sulfur atoms, as well as the obligatory hydrogen and carbon atoms, elements that have an unfavourable isotope distribution when it comes to NMR spectroscopy. Each of these three elements has a dominant isotope: 14 16 32 16 32 N (99. 63% natural abundance), O (99. 76%), and S (95. 02%), with O, S, and 34 14 S (4. 21%) NMR silent. N has a nuclear moment I = 1 and a sizeable quadrupolar moment that makes the NMR signals usually very broad and dif cult to analyse.
During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book covers the entire area of NMR in Biological Sciences (Biomolecules, cells and tissues, animals, plants and drug design). As well as being useful to researchers, this is an excellent book for teaching a course on NMR in Biological Systems.
DIV ‘Marco Roth’s book about his father is a farewell to a bygone culture – polygot, intellectual, Europhile, psychoanalytic – and simultaneously a renewal of that culture. It’s moving, tough-minded, and distinctive, a memoir the likes of which nobody else could write.’ Benjamin Kunkel, author of Indecision With the precociousness expected of the only child of a doctor and a classical musician – from the time he could get his toddler tongue to pronounce a word like ‘deoxyribonucleic acid’ or recite a French poem – Marco Roth was able to share his parents’ New York, a world centered around house concerts, a private library of literary classics, and dinner discussions of the latest advances in medicine. That world ended when his father began to suffer the worst effects of the AIDS virus that had infected him in the early 1980s. What this family would not talk about for years came to dominate the lives of its surviving members, often in unexpected ways. The Scientists is a story of how we first learn from our parents and how we then learn to see them as separate individuals; it’s a story of how preciousness can slow us down when it comes to understanding our desires and other people’s. A memoir of parents and children in the tradition of Edmund Gosse, Henry Adams and J. R. Ackerley, The Scientists grapples with a troubled and emotional inheritance, in a style that is both elegiac and defiant. /div
The field of nuclear magnetic resonance has experienced a number of spectacular developments during the last decade. Fourier transform methodology revolutionized signal acquisition capabilities. Superconducting magnets enhanced sensitivity and produced considerable improvement in spectral dispersion. In areas of new applicat ions, the life sciences particularly bene fited from these developments and probably saw the largest increase in usage. NMR imaging promises to offer a noninvasive alternative to X rays. High resolution is now achievable with solids, through magic angle spinning and cross polarization, so that the powers of NMR are applicable to previously intractable materials such as polymers, coal, and other geochemicals. The ease of obtaining relaxation times brought an important fourth variable, after the chemical shift, the coupling constant, and the rate constant, to the examination of structural and kinetic problems i~ all fields. Software development, particularly in the area of pulse sequences, created a host of useful tech niques, including difference decoupling and difference nuclear Overhauser effect spectra, multidimensional displays, signal enhancement (INEPT), coupling constant analysis for connectivity (INADEQUATE), and observation of specific structural classes such as only quaternary carbons. Finally, hardware development gave us access to the entire Periodic Table, to the particular advan tage of the inorganic and organometallic chemist. At the NATO Advanced Study Institute at Stirling, Scotland, the participants endeavored to examine all these advances, except imaging, from a multidisciplinary point of view.
Solving Problems with NMR Spectroscopy presents the basic principles and applications of NMR spectroscopy with only as much math as is necessary. It shows how to solve chemical structures with NMR by giving clear examples and solutions. This text will enable organic chemistry students to choose the most appropriate NMR techniques to solve specific structures. The problems to work and the discussion of their solutions and interpretations will help readers becomeproficient in the application of important, modern 1D and 2D NMR techniques to structural studies. Key Features * Presents the most important NMR techniques for structural determinations * Offers a unique problem-solving approach * Uses questions and problems, including discussions of their solutions and interpretations, to help readers grasp NMR * Avoids extensive mathematical formulas * Forewords by Nobel Prize winner Richard R. Ernst and Lloyd M. Jackman

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